Tomato Spotted Wilt Virus Suppresses the Antiviral Response of the Insect Vector, <i>Frankliniella occidentalis</i>, by Elevating an Immunosuppressive C18 Oxylipin Level Using Its Virulent Factor, NSs.

ABSTRACT: Orthotospovirus tomatomaculae (tomato spotted wilt virus, TSWV) is transmitted by the western flower thrips, Frankliniella occidentalis. Epoxyoctadecamonoenoic acids (EpOMEs) function as immune-suppressive factors, particularly in insects infected by viral pathogens. These oxylipins are produced by cytochrome P450 monooxygenases (CYPs) and are degraded by soluble epoxide hydrolase (sEH). In this study, we tested the hypothesis that TSWV modulates the EpOME level in the thrips to suppress antiviral responses and enhance its replication. TSWV infection significantly elevated both 9,10-EpOME and 12,13-EpOME levels. Following TSWV infection, the larvae displayed apoptosis in the midgut along with the upregulated expression of four caspase genes. However, the addition of EpOME to

SUBMITTER: Shahmohammadi N 

PROVIDER: S-EPMC11352781 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature