Amplified Cell Cycle Genes Identified in High-Grade Serous Ovarian Cancer.

ABSTRACT: The objective of this study was to identify differentially expressed genes and their potential influence on the carcinogenesis of serous-type ovarian cancer tumors. Serous cancer is an epithelial ovarian cancer subtype and is the most common type of ovarian cancer. Transcriptomic profiles of serous cancer and non-cancerous datasets were obtained from the Gene Expression Omnibus (GEO-NCBI). Differentially expressed genes were then derived from those profiles; the identified genes were consistently upregulated in three or more transcriptomic profiles. These genes were considered as the serous ovarian cancer gene set for further study. The serous gene set derived from the transcriptomic profiles was then evaluated for ontological functional analysis using the Molecular Signatures Database. Ne

SUBMITTER: Balakrishnan K 

PROVIDER: S-EPMC11352846 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature