Association of Maternal Air Pollution Exposure and Infant Lung Function Is Modified by Genetic Propensity to Oxidative Stress.

ABSTRACT:

Background and objective

The association between air pollution and poor respiratory health outcomes is well established. Children are particularly at risk from air pollution, especially during the prenatal period as their organs and systems are still undergoing crucial development. This study investigated maternal exposure to air pollution during pregnancy and oxidative stress (OS), inflammation, and infant lung function at 4 weeks of age.

Methods

Data from the Barwon Infant Study were available for 314 infants. The exposure to NO₂ and PM_2.5 were estimated. Infant lung function (4 weeks) was measured by multiple-breath washout. Glycoprotein acetyls (GlycA) (36 weeks prenatal), cord blood, and OS biomarkers were measured in maternal urine (28 weeks). A g

SUBMITTER: Vilcins D 

PROVIDER: S-EPMC11352943 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature