DNA Methylation of PXDN Is Associated with Early-Life Adversity in Adult Mental Disorders.

ABSTRACT: Early-life adversity (ELA) is characterized by exposure to traumatic events during early periods of life, particularly involving emotional, sexual and/or physical adversities during childhood. Mental disorders are strongly influenced by environmental and lifestyle-related risk factors including ELA. However, the molecular link between ELA and the risk of an adult mental disorder is still not fully understood. Evidence is emerging that long-lasting changes in the epigenetic processes regulating gene expression, such as DNA methylation, play an important role in the biological mechanisms linking ELA and mental disorders. Based on a recent study, we analyzed the DNA methylation of a specific CpG site within the gene PXDN-cg10888111-in blood in the context of ELA across a set of psychia

SUBMITTER: Edelmann S 

PROVIDER: S-EPMC11353138 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature