Transcriptome Analysis Reveals Novel Inflammatory Signalings to Glaesserella parasuis Infection.

ABSTRACT: Glaesserella parasuis (GPS) can cause severe systemic inflammation in pigs, resulting in huge economic losses to the pig industry. At present, no effective method is available for the prevention and control of GPS infection. Molecular breeding for disease resistance is imminent, but disease-resistance genes have not been identified. To study the mechanism of systemic acute inflammation caused by GPS, we established three in vitro infection models (3D4/21 cells, PK15 cells, and PAVEC cells) according to its infection path. There was no significant difference in apoptosis among the three kinds of cells after 12 h of continuous GPS stimulation, while inflammatory factors were significantly upregulated. Subsequent transcriptome analysis revealed 1969, 1207, and 3564 differentially expre

SUBMITTER: Lei J 

PROVIDER: S-EPMC11353251 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature