Circulating miRNA Signaling for Fatty Acid Metabolism in Response to a Maximum Endurance Test in Elite Long-Distance Runners.

ABSTRACT: Maximal oxygen uptake (VO₂max) is a determining indicator for cardiorespiratory capacity in endurance athletes, and epigenetics is crucial in its levels and variability. This initial study examined a broad plasma miRNA profile of twenty-three trained elite endurance athletes with similar training volumes but different VO₂max in response to an acute maximal graded endurance test. Six were clustered as higher/lower levels based on their VO₂max (75.4 ± 0.9 and 60.1 ± 5.0 mL.kg^-1.min^-1). Plasma was obtained from athletes before and after the test and 15 ng of total RNA was extracted and detected using an SYBR-based 1113 miRNA RT-qPCR panel. A total of 51 miRNAs were differentially expressed among group comparisons. Relative amounts of miRN

SUBMITTER: Paulucio D 

PROVIDER: S-EPMC11353293 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature