Bioinformatics for Inosine: Tools and Approaches to Trace This Elusive RNA Modification.

ABSTRACT: Inosine is a nucleotide resulting from the deamination of adenosine in RNA. This chemical modification process, known as RNA editing, is typically mediated by a family of double-stranded RNA binding proteins named Adenosine Deaminase Acting on dsRNA (ADAR). While the presence of ADAR orthologs has been traced throughout the evolution of metazoans, the existence and extension of RNA editing have been characterized in a more limited number of animals so far. Undoubtedly, ADAR-mediated RNA editing plays a vital role in physiology, organismal development and disease, making the understanding of the evolutionary conservation of this phenomenon pivotal to a deep characterization of relevant biological processes. However, the lack of direct high-throughput methods to reveal RNA modifications at s

SUBMITTER: Bortoletto E 

PROVIDER: S-EPMC11353476 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature