Ex Vivo Study of Colon Health, Contractility and Innervation in Male and Female Rats after Regular Exposure to Instant Cascara Beverage.

ABSTRACT: Instant Cascara (IC) is a sustainable beverage made from dried coffee cherry pulp, a by-product of coffee processing. It is rich in nutrients and bioactive compounds and has a high concentration of antioxidants. This study explored the impact of regular IC consumption on colonic motor function and innervation. Over a period of 4 weeks, male and female healthy rats were given drinking water containing 10 mg/mL of IC. Thereafter, colon samples were obtained to evaluate the longitudinal (LM) and circular (CM) smooth muscle contractile response to acetylcholine (ACh) and electrical field stimulation (EFS) in an organ bath, before and after atropine administration (10^-6 M). Histological and immunohistochemical analyses assessed colon damage, muscle thickness, and immunoreactivity to

SUBMITTER: Gallego-Barcelo P 

PROVIDER: S-EPMC11353626 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature