PON1 Status in Relation to Gulf War Illness: Evidence of Gene-Exposure Interactions from a Multisite Case-Control Study of 1990-1991 Gulf War Veterans.

ABSTRACT:

Background

Deployment-related neurotoxicant exposures are implicated in the etiology of Gulf War illness (GWI), the multisymptom condition associated with military service in the 1990-1991 Gulf War (GW). A Q/R polymorphism at position 192 of the paraoxonase (PON)-1 enzyme produce PON1₁₉₂ variants with different capacities for neutralizing specific chemicals, including certain acetylcholinesterase inhibitors.

Methods

We evaluated PON1₁₉₂ status and GW exposures in 295 GWI cases and 103 GW veteran controls. Multivariable logistic regression determined independent associations of GWI with GW exposures overall and in PON1₁₉₂ subgroups. Exact logistic regression explored effects of exposure combinations in PON1₁₉₂ subgroups.

Results<

SUBMITTER: Steele L 

PROVIDER: S-EPMC11353671 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature