Metabolomic markers mediate erythrocyte anisocytosis in older adults: Results from three independent aging cohorts.

ABSTRACT:

Background

Anisocytosis reflects unequal-sized red blood cells and is quantified using red blood cell distribution width (RDW). RDW increases with age and has been consistently associated with adverse health outcomes, such as cardiovascular disease and mortality. Why RDW increases with age is not understood. We aimed to identify plasma metabolomic markers mediating anisocytosis with aging.

Methods

We performed mediation analyses of plasma metabolomics on the association between age and RDW using resampling techniques after covariate adjustment. We analyzed data from adults aged 70 or older from the main discovery cohort of the Baltimore Longitudinal Study of Aging (BLSA, n = 477, 46% women) and validation cohorts of the Health, Aging and Body Composition Study (Health ABC, n

SUBMITTER: Tian Q 

PROVIDER: S-EPMC11353686 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature