Simulated Microgravity Alters Gene Regulation Linked to Immunity and Cardiovascular Disease.

ABSTRACT: Microgravity exposure induces a cephalad fluid shift and an overall reduction in physical activity levels which can lead to cardiovascular deconditioning in the absence of countermeasures. Future spaceflight missions will expose crew to extended periods of microgravity among other stressors, the effects of which on cardiovascular health are not fully known. In this study, we determined cardiac responses to extended microgravity exposure using the rat hindlimb unloading (HU) model. We hypothesized that exposure to prolonged simulated microgravity and subsequent recovery would lead to increased oxidative damage and altered expression of genes involved in the oxidative response. To test this hypothesis, we examined hearts of male (three and nine months of age) and female (3 months of age) Lon

SUBMITTER: Tahimic CGT 

PROVIDER: S-EPMC11353732 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature