Whole Genome Analysis in Consanguineous Families Reveals New Loci for Speech Sound Disorder (SSD).

ABSTRACT: Speech is the most common means of communication in humans. Any defect in accurate speech production ability results in the development of speech sound disorder (SSD), a condition that can significantly impair an individual's academic performance, social interactions, and relationships with peers and adults. This study investigated the genetic basis of SSD in three Pakistani families. We performed family-based genome-wide parametric linkage analysis and homozygosity mapping in three consanguineous families with SSD from the Punjab province of Pakistan. The Test for Assessment of Articulation and Phonology in Urdu (TAAPU) was used to analyze the speech articulation data and determine the Percentage Correct Consonants (PCC) score. The PCC score defined the affected and unaffected individuals

SUBMITTER: Yasmin T 

PROVIDER: S-EPMC11354014 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature