Primary Progressive Multiple Sclerosis-A Key to Understanding and Managing Disease Progression.

ABSTRACT: Primary progressive multiple sclerosis (PPMS), the least frequent type of multiple sclerosis (MS), is characterized by a specific course and clinical symptoms, and it is associated with a poor prognosis. It requires extensive differential diagnosis and often a long-term follow-up before its correct recognition. Despite recent progress in research into and treatment for progressive MS, the diagnosis and management of this type of disease still poses a challenge. Considering the modern concept of progression "smoldering" throughout all the stages of disease, a thorough exploration of PPMS may provide a better insight into mechanisms of progression in MS, with potential clinical implications. The goal of this study was to review the current evidence from investigations of PPMS, including its

SUBMITTER: Sempik I 

PROVIDER: S-EPMC11354232 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature