Melatonin Alleviates Liver Mitochondrial Dysfunction in Leptin-Deficient Mice.

ABSTRACT: Despite efforts to elucidate the cellular adaptations induced by obesity, cellular bioenergetics is currently considered a crucial target. New strategies to delay the onset of the hazardous adaptations induced by obesity are needed. Therefore, we evaluated the effects of 4 weeks of melatonin treatment on mitochondrial function and lipid metabolism in the livers of leptin-deficient mice. Our results revealed that the absence of leptin increased lipid storage in the liver and induced significant mitochondrial alterations, which were ultimately responsible for defective ATP production and reactive oxygen species overproduction. Moreover, leptin deficiency promoted mitochondrial biogenesis, fusion, and outer membrane permeabilization. Melatonin treatment reduced the bioenergetic deficit found

SUBMITTER: de Luxan-Delgado B 

PROVIDER: S-EPMC11354344 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature