Disturbance of Immune Microenvironment in Androgenetic Alopecia through Spatial Transcriptomics.

ABSTRACT: Androgenetic alopecia (AGA) is characterized by microinflammation and abnormal immune responses, particularly in the upper segment of hair follicles (HFs). However, the precise patterns of immune dysregulation remain unclear, partly due to limitations in current analysis techniques to preserve tissue architecture. The infundibulum, a major part of the upper segment of HFs, is associated with significant clusters of immune cells. In this study, we investigated immune cells around the infundibulum, referred to as peri-infundibular immune infiltration (PII). We employed spatial transcriptome profiling, a high-throughput analysis technology, to investigate the immunological disruptions within the PII region. Our comprehensive analysis included an evaluation of overall immune infiltrates, gene

SUBMITTER: Charoensuksira S 

PROVIDER: S-EPMC11354591 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature