Genome Mining and Genetic Manipulation Reveal New Isofuranonaphthoquinones in Nocardia Species.

ABSTRACT: The identification of specialized metabolites isolated from microorganisms is urgently needed to determine their roles in treating cancer and controlling multidrug-resistant pathogens. Naphthoquinones act as anticancer agents in various types of cancers, but some toxicity indicators have been limited in their appropriate application. In this context, new isofuranonaphthoquinones (ifnq) that are less toxic to humans could be promising lead compounds for developing anticancer drugs. The aim of this study is to identify and characterize novel furanonaphthoquinones (fnqs) from Nocardia sp. CS682 and to evaluate their potential therapeutic applications. Analysis of the genome of Nocardia sp. CS682 revealed the presence of a furanonaphthoquinone (fnq) gene cluster, which dis

SUBMITTER: Poudel PB 

PROVIDER: S-EPMC11354674 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature