In Vitro Assay Development to Study Pulse Field Ablation Outcome Using Solanum Tuberosum.

ABSTRACT: Exposing cells to intense and brief electric field pulses can modulate cell permeability, a phenomenon termed electroporation. When applied in medical treatments of diseases like cancer and cardiac arrhythmias, depending on level of cellular destruction, it is also referred to as irreversible electroporation (IRE) or Pulsed Field Ablation (PFA). For ablation device testing, several pulse parameters need to be characterized in a comprehensive manner to assess lesion boundary and efficacy. Overly aggressive voltages and application numbers increase animal burden. The potato tuber is a widely used initial model for the early testing of electroporation. The aim of this study is to characterize and refine bench testing for the ablation outcomes of PFA in this simplistic vegetal model. For in vi

SUBMITTER: Narkar A 

PROVIDER: S-EPMC11354718 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature