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Antitumoral and Antimetastatic Activity by Mixed Chelate Copper(II) Compounds (Casiopeinas^®) on Triple-Negative Breast Cancer, In Vitro and In Vivo Models.

ABSTRACT: Triple-negative breast cancer (TNBC), accounting for 15-20% of all breast cancers, has one of the poorest prognoses and survival rates. Metastasis, a critical process in cancer progression, causes most cancer-related deaths, underscoring the need for alternative therapeutic approaches. This study explores the anti-migratory, anti-invasive, anti-tumoral, and antimetastatic effects of copper coordination compounds Casiopeína IIIia (CasIIIia) and Casiopeína IIgly (CasIIgly) on MDA-MB-231 and 4T1 breast carcinoma cell lines in vitro and in vivo. These emerging anticancer agents, mixed chelate copper(II) compounds, induce apoptosis by generating reactive oxygen species (ROS) and causing DNA damage. Whole-transcriptome analysis via gene expression arrays indicated that subtoxic concentrations of

SUBMITTER: Gonzalez-Ballesteros MM

PROVIDER: S-EPMC11354730 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Antitumoral and Antimetastatic Activity by Mixed Chelate Copper(II) Compounds (Casiopeinas^®) on Triple-Negative Breast Cancer, In Vitro and In Vivo Models.

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Dataset Information

Antitumoral and Antimetastatic Activity by Mixed Chelate Copper(II) Compounds (Casiopeinas®) on Triple-Negative Breast Cancer, In Vitro and In Vivo Models.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Antitumoral and Antimetastatic Activity by Mixed Chelate Copper(II) Compounds (Casiopeinas^®) on Triple-Negative Breast Cancer, In Vitro and In Vivo Models.