Hydrogen Bond Strengthens Acceptor Group: The Curious Case of the C-H···O=C Bond.

ABSTRACT: An H-bond involves the sharing of a hydrogen atom between an electronegative atom to which it is covalently bound (the donor) and another electronegative atom serving as an acceptor. Such bonds represent a critically important geometrical force in biological macromolecules and, as such, have been characterized extensively. H-bond formation invariably leads to a weakening within the acceptor moiety due to the pulling exerted by the donor hydrogen. This phenomenon can be compared to a spring connecting two masses; pulling one mass stretches the spring, similarly affecting the bond between the two masses. Herein, we describe the opposite phenomenon when investigating the energetics of the C-H···O=C bond. This bond underpins the most prevalent protein transmembrane dimerization motif (GxxxG) i

SUBMITTER: Basu K 

PROVIDER: S-EPMC11354782 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature