Glutathione-S-Transferase Theta 2 (GSTT2) Modulates the Response to Bacillus Calmette-Guerin Immunotherapy in Bladder Cancer Patients.

ABSTRACT: Glutathione-S-transferases (GST) enzymes detoxify xenobiotics and are implicated in response to anticancer therapy. This study evaluated the association of GST theta 1 (GSTT1), GSTT2, and GSTT2B with Mycobacterium bovis Bacillus Calmette-Guérin (BCG) response in non-muscle-invasive bladder cancer treatment. In vitro assessments of GSTT2 knockout (KO) effects were performed using cell lines and dendritic cells (DCs) from GSTT2KO mice. Deletion of GSTT2B, GSTT1, and single-nucleotide polymorphisms in the promoter region of GSTT2 was analysed in patients (n = 205) and healthy controls (n = 150). Silencing GSTT2 expression in MGH cells (GSTT2B^FL/FL) resulted in increased BCG survival (p < 0.05) and decreased cellular reactive oxygen species. In our population, t

SUBMITTER: Rahmat JN 

PROVIDER: S-EPMC11354831 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature