High-Frequency Imaging Reveals Synchronised Delta- and Theta-Band Ca²⁺ Oscillations in the Astrocytic Soma In Vivo.

ABSTRACT: One of the major breakthroughs of neurobiology was the identification of distinct ranges of oscillatory activity in the neuronal network that were found to be responsible for specific biological functions, both physiological and pathological in nature. Astrocytes, physically coupled by gap junctions and possessing the ability to simultaneously modulate the functions of a large number of surrounding synapses, are perfectly positioned to introduce synchronised oscillatory activity into the neural network. However, astrocytic somatic calcium signalling has not been investigated to date in the frequency ranges of common neuronal oscillations, since astrocytes are generally considered to be slow responders in terms of Ca²⁺ signalling. Using high-frequency two-photon imaging, we revea

SUBMITTER: Peter M 

PROVIDER: S-EPMC11354863 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature