A Cross-Sectional Analysis of Interventional Clinical Trials in High-Grade Glioma Therapy.

ABSTRACT: High-grade glioma is the most frequent and lethal primary tumor of the central nervous system. Despite advances in surgical, pharmacological, and cell-directed therapies, there have been no updates to the standard of care in over a decade. This cross-sectional study analyzes patient and trial data from 201 interventional trials completed between 2010 and 2023, encompassing 18,563 participants. Although we found that all trials reported participant age and sex, only 52% of trials reported participant demographics, resulting in 51% of total participant demographics being unreported. The majority of studies did not report ethnicity, with approximately 60% of participants unreported. Additionally, males were significantly underrepresented in trials, comprising 60% of participants despite repre

SUBMITTER: Angione A 

PROVIDER: S-EPMC11355386 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature