Metabolic and Oxidative Stress Management Heterogeneity in a Panel of Breast Cancer Cell Lines.

ABSTRACT: Metabolic alterations are recognized as one of the hallmarks of cancer. Among these, alterations in mitochondrial function have been associated with an enhanced production of Reactive Oxygen Species (ROS), which activate ROS-regulated cancer cell signaling pathways. Breast cancer is the main cancer-related cause of death for women globally. It is a heterogeneous disease with subtypes characterized by specific molecular features and patient outcomes. With the purpose of identifying differences in energy metabolism and the oxidative stress management system in non-tumorigenic, estrogen receptor positive (ER+) and triple negative (TN) breast cancer cells, we evaluated ROS production, protein enzyme levels and activities and profiled energy metabolism. We found differences in energetic metabol

SUBMITTER: Maycotte P 

PROVIDER: S-EPMC11356218 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature