Alteration of Trophoblast Syncytialization by Plasmodium falciparum-Infected Erythrocytes.

ABSTRACT: Malaria during pregnancy has been associated with significant risks to both the mother and the fetus, leading to complications such as anemia, low birth weight, and increased infant mortality. The trophoblast cells, a key component of the placenta, are crucial for nutrient and oxygen exchange between mother and fetus. The differentiation of cytotrophoblasts (CTBs) into syncytiotrophoblasts (STBs) is critical for proper pregnancy development. These cells form the bi-stratified epithelium surrounding the placental villi. While previous studies have described an inflammatory activation of STB cells exposed to Plasmodium falciparum-infected erythrocytes (P. falciparum-IE) or components such as hemozoin (HZ), little is known about the direct effect this parasite may have on the ep

SUBMITTER: Lopez-Guzman C 

PROVIDER: S-EPMC11356531 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature