Population-based screening strategies for biliary atresia in the newborn: A systematic review and meta-analysis.

ABSTRACT:

Background

Newborn screening for biliary atresia (BA) may facilitate earlier diagnosis and intervention for improved clinical outcomes.

Methods

We systematically reviewed the accuracy of population-based screening strategies for BA in the newborn using PRISMA-DTA guidelines. We included cohort or cross-sectional studies. The screening (index) tests included stool color card (SCC) and direct/conjugated bilirubin (DB/CB) and the reference standard was intraoperative cholangiogram. Meta-analysis was performed using random-effects logistic regression models.

Results

We included 15 studies (1,816,722 participants) that assessed 5 different population-based screening strategies. QUADAS-2 assessment revealed high risk of bias for patient selection in one study and uncertain

SUBMITTER: Gopal SH 

PROVIDER: S-EPMC11357077 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature