Kalanchoe tomentosa: Phytochemical Profiling, and Evaluation of Its Biological Activities In Vitro, In Vivo, and In Silico.

ABSTRACT: In this work, the leaves of K. tomentosa were macerated with hexane, chloroform, and methanol, respectively. The phytochemical profiles of hexane and chloroform extracts were unveiled using GC/MS, whereas the chemical composition of the methanol extract was analyzed using UPLC/MS/MS. The antibacterial activity of extracts was determined against gram-positive and gram-negative strains through the minimal inhibitory concentration assay, and in silico studies were implemented to analyze the interaction of phytoconstituents with bacterial peptides. The antioxidant property of extracts was assessed by evaluating their capacity to scavenge DPPH, ABTS, and H₂O₂ radicals. The toxicity of the extracts was recorded against Artemia salina nauplii and Caen

SUBMITTER: Mejia-Mendez JL 

PROVIDER: S-EPMC11357309 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature