Baculovirus-Assisted Production of <i>Bartonella bacilliformis</i> Proteins: A Potential Strategy for Improving Serological Diagnosis of Carrion's Disease.

ABSTRACT: Carrion's disease, caused by Bartonella bacilliformis, is a neglected tropical disease prevalent in the Andean region of South America. Without antimicrobial treatment, this disease has a mortality rate of up to 88% in infected patients. The most common method for diagnosing B. bacilliformis infection is serological testing. However, the current serological assays are limited in sensitivity and specificity, underscoring the need for the development of novel and more accurate diagnostic tools. Recombinant proteins have emerged as promising candidates to improve the serological diagnosis of Carrion's disease. So, we focused on evaluating the conditions for producing two previously predicted proteins of B. bacilliformis using the baculovirus-insect cell expression system,

SUBMITTER: Vilca-Machaca LS 

PROVIDER: S-EPMC11357310 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature