Senescent cells inhibit mouse myoblast differentiation via the SASP-lipid 15d-PGJ₂ mediated modification and control of HRas.

ABSTRACT: Senescent cells are characterized by multiple features such as increased expression of senescence-associated β-galactosidase activity (SA β-gal) and cell cycle inhibitors such as p21 or p16. They accumulate with tissue damage and dysregulate tissue homeostasis. In the context of skeletal muscle, it is known that agents used for chemotherapy such as Doxorubicin (Doxo) cause buildup of senescent cells, leading to the inhibition of tissue regeneration. Senescent cells influence the neighboring cells via numerous secreted factors which form the senescence-associated secreted phenotype (SASP). Lipids are emerging as a key component of SASP that can control tissue homeostasis. Arachidonic acid-derived lipids have been shown to accumulate within senescent cells, specifically 15d-PGJ₂,

SUBMITTER: Pundlik SS 

PROVIDER: S-EPMC11357351 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature