Feedback inhibition by a descending GABAergic neuron regulates timing of escape behavior in Drosophila larvae.

ABSTRACT: Escape behaviors help animals avoid harm from predators and other threats in the environment. Successful escape relies on integrating information from multiple stimulus modalities (of external or internal origin) to compute trajectories toward safe locations, choose between actions that satisfy competing motivations, and execute other strategies that ensure survival. To this end, escape behaviors must be adaptive. When a Drosophila melanogaster larva encounters a noxious stimulus, such as the focal pressure a parasitic wasp applies to the larval cuticle via its ovipositor, it initiates a characteristic escape response. The escape sequence consists of an initial abrupt bending, lateral rolling, and finally rapid crawling. Previous work has shown that the detection of noxious stimuli

SUBMITTER: Zhu J 

PROVIDER: S-EPMC11357356 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature