The Influence of 2'-Deoxyguanosine Lesions on the Electronic Properties of ^OXOG:::C Base Pairs in Ds-DNA: A Comparative Analysis of Theoretical Studies.

ABSTRACT: DNA is continuously exposed to a variety of harmful factors, which, on the one hand, can force undesirable processes such as ageing, carcinogenesis and mutagenesis, while on the other hand, can accelerate evolutionary changes. Of all the canonical nucleosides, 2'-deoxyguanosine (dG) exhibits the lowest ionization potential, making it particularly prone to the one-electron oxidizing process. The most abundant type of nucleobase damage is constituted by 7,8-dihydro-8-oxo-2'-deoxyguanosine (^OXOdG), with an oxidation potential that is 0.56 V lower than that of canonical dG. All this has led to ^OXOdG, as an isolated lesion, being perceived as a sink for radical cations in the genome. In this paper, a comparative analysis of the electronic properties of an ^OXOGC

SUBMITTER: Karwowski BT 

PROVIDER: S-EPMC11357419 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature