A Compound Containing Aldehyde Dehydrogenase Relieves the Effects of Alcohol Consumption and Hangover Symptoms in Healthy Men: An Open-Labeled Comparative Study.

ABSTRACT: This open-labeled and comparative study aimed to test the efficacy and safety of a fermented rice extract-based substance containing yeast-fermented powder having aldehyde dehydrogenase (KisLip^®, Pico Entech, Republic of Korea) in healthy male individuals. Healthy male subjects (n = 20) consumed 90 g of alcohol at their first visit. At the second visit, participants consumed 90 g of alcohol or alcohol with a low dose of KISLip^® (2000 mg, KL-L) and then 90 g of alcohol or alcohol with a high dose of KISLip^® (3000 mg, KL-H) at the third visit. The efficacy of KISLip^® depends on the mutational status of important genes related to alcohol metabolism, including alcohol dehydrogenase (ADH1B), cytochrome P4502E1 (CYP2E1 (5B) and

SUBMITTER: Jeong IK 

PROVIDER: S-EPMC11357502 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature