Insights into Peptidyl-Prolyl <i>cis</i>-<i>trans</i> Isomerases from Clinically Important Protozoans: From Structure to Potential Biotechnological Applications.

ABSTRACT: Peptidyl-prolyl cis/trans isomerases (PPIases) are present in a wide variety of microorganisms, including protozoan parasites such as Trypanosoma cruzi, Trypanosoma brucei, Trichomonas vaginalis, Leishmania major, Leishmania donovani, Plasmodium falciparum, Plasmodium vivax, Entamoeba histolytica, Giardia intestinalis, Cryptosporidium parvum, and Cryptosporidium hominis, all of which cause important neglected diseases. PPIases are classified as cyclophilins, FKBPs, or parvulins and play crucial roles in catalyzing the cis-trans isomerization of the peptide bond preceding a proline residue. This activity assists in correct protein folding. However, experimentally, the biological structure-funct

SUBMITTER: Aranda-Chan V 

PROVIDER: S-EPMC11357558 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature