Comparative Genomic Analysis of Prophages in Human Vaginal Isolates of <i>Streptococcus agalactiae</i>.

ABSTRACT: Prophages, viral genomes integrated into bacterial genomes, are known to enhance bacterial colonization, adaptation, and ecological fitness, providing a better chance for pathogenic bacteria to disseminate and cause infection. Streptococcus agalactiae (Group B Streptococcus or GBS) is a common bacterium found colonizing the genitourinary tract of humans. However, GBS-colonized pregnant women are at risk of passing the organism to the neonate, where it can cause severe infections. GBS typically encode one or more prophages in their genomes, yet their role in pathogen fitness and virulence has not yet been described. Sequencing and bioinformatic analysis of the genomic content of GBS human isolates identified 42 complete prophages present in their genomes. Comparative genomic analyses

SUBMITTER: Wiafe-Kwakye CS 

PROVIDER: S-EPMC11357604 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature