Stimulating the Antitumor Immune Response Using Immunocytokines: A Preclinical and Clinical Overview.

ABSTRACT: Cytokines are immune modulators which can enhance the immune response and have been proven to be an effective class of immunotherapy. Nevertheless, the clinical use of cytokines in cancer treatment has faced several challenges associated with poor pharmacokinetic properties and the occurrence of adverse effects. Immunocytokines (ICKs) have emerged as a promising approach to overcome the pharmacological limitations observed with cytokines. ICKs are fusion proteins designed to deliver cytokines in the tumor microenvironment by taking advantage of the stability and specificity of immunoglobulin-based scaffolds. Several technological approaches have been developed. This review focuses on ICKs designed with the most impactful cytokines in the cancer field: IL-2, TNFα, IL-10, IL-12, IL-15, IL-21

SUBMITTER: Boersma B 

PROVIDER: S-EPMC11357675 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature