Balancing benefits and limitations of linear energy transfer optimization in carbon ion radiotherapy for large sacral chordomas.

ABSTRACT:

Background and purpose

A low linear energy transfer (LET) in the target can reduce the effectiveness of carbon ion radiotherapy (CIRT). This study aimed at exploring benefits and limitations of LET optimization for large sacral chordomas (SC) undergoing CIRT.

Materials and methods

Seventeen cases were used to tune LET-based optimization, and seven to independently test interfraction plan robustness. For each patient, a reference plan was optimized on biologically-weighted dose cost functions. For the first group, 7 LET-optimized plans were obtained by increasing the gross tumor volume (GTV) minimum LET_d (minLET_d) in the range 37-55 keV/μm, in steps of 3 keV/μm. The optimal LET-optimized plan (LET_OPT) was the one maximizing LET_d, wh

SUBMITTER: Parrella G 

PROVIDER: S-EPMC11357807 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature