Focus on cardiac troponin complex: From gene expression to cardiomyopathy.

ABSTRACT: The cardiac troponin complex (cTn) is a regulatory component of sarcomere. cTn consists of three subunits: cardiac troponin C (cTnC), which confers Ca²⁺ sensitivity to muscle; cTnI, which inhibits the interaction of cross-bridge of myosin with thin filament during diastole; and cTnT, which has multiple roles in sarcomere, such as promoting the link between the cTnI-cTnC complex and tropomyosin within the thin filament and influencing Ca²⁺ sensitivity of cTn and force development during contraction. Conditions that interfere with interactions within cTn and/or other thin filament proteins can be key factors in the regulation of cardiac contraction. These conditions include alterations in myofilament Ca²⁺ sensitivity, direct changes in cTn function, and trigg

SUBMITTER: Ragusa R 

PROVIDER: S-EPMC11357864 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature