Multi-omics characterization of type 2 diabetes mellitus-induced gastroenteropathy in the db/db mouse model.

ABSTRACT:

Objective

Gastrointestinal dysfunction are often associated with type 2 diabetes mellitus (T2DM), a complicated metabolic illness. Contributing factors have been proposed, including genetic predisposition, gene environmental, and lifestyle interactions, but the pathophysiology remains unknown.

Methods

We aim to explore the possible causes behind gastrointestinal dysfunction caused by type 2 diabetes in this study. A comprehensive analysis of the gastric sinus metabolome, transcriptome, and proteome in db/db mice with gastrointestinal dysfunction was conducted.

Results

The model group of mice had considerably lower small intestine propulsion and gastric emptying rates, higher blood glucose levels, and were significantly obese compared to the control group. We identifie

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11357919 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature