γδ T cell-mediated activation of cDC1 orchestrates CD4⁺ Th1 cell priming in malaria.

ABSTRACT: γδ T cells facilitate the CD4⁺ T helper 1 (Th1) cell response against Plasmodium infection by activating conventional dendritic cells (cDCs), although the underlying mechanism remains elusive. Our study revealed that γδ T cells promote the complete maturation and production of interleukin-12 and CXCR3-ligands specifically in type 1 cDCs (cDC1), with minimal impact on cDC2 and monocyte derived DCs (Mo-DCs). During the initial infection phase, γδ T cell activation and temporal accumulation in the splenic white pulp, alongside cDC1, occur via CCR7-signaling. Furthermore, cDC1/γδ T cell interactions in the white pulp are amplified through CXCR3 signaling in γδ T cells, optimizing Th1 cell priming by cDC1. We also demonstrated how transitional Th1 cells arise in the white pulp

SUBMITTER: Ibraheem Y 

PROVIDER: S-EPMC11357926 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature