Immune signaling pathways in Rhodnius prolixus in the context of Trypanosoma rangeli infection: cellular and humoral immune responses and microbiota modulation.

ABSTRACT:

Introduction

Rhodnius prolixus is a hematophagous insect and one of the main vectors for Trypanosoma cruzi and Trypanosoma rangeli parasites in Latin America. Gut microbiota and insect immune responses affect T. cruzi and T. rangeli infection within triatomines. Particularly the Toll and IMD signaling pathways activations and how they orchestrate the antimicrobial peptides (AMPs) expressions in R. prolixus, especially when infected by T. rangeli.

Objectives

Examine how T. rangeli infection modulates R. prolixus cellular and humoral immunity and its impacts on insect microbiota.

Methods

R. prolixus was fed on blood containing epimastigotes of T. rangeli, and infection was quantified in insect

SUBMITTER: Pereira SB 

PROVIDER: S-EPMC11357937 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature