Molecular and physiological changes in the SpaceX Inspiration4 civilian crew.

ABSTRACT: Human spaceflight has historically been managed by government agencies, such as in the NASA Twins Study¹, but new commercial spaceflight opportunities have opened spaceflight to a broader population. In 2021, the SpaceX Inspiration4 mission launched the first all-civilian crew to low Earth orbit, which included the youngest American astronaut (aged 29), new in-flight experimental technologies (handheld ultrasound imaging, smartwatch wearables and immune profiling), ocular alignment measurements and new protocols for in-depth, multi-omic molecular and cellular profiling. Here we report the primary findings from the 3-day spaceflight mission, which induced a broad range of physiological and stress responses, neurovestibular changes indexed by ocular misalignment, and altered neuro

SUBMITTER: Jones CW 

PROVIDER: S-EPMC11357997 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature