Gut microbiota carcinogen metabolism causes distal tissue tumours.

ABSTRACT: Exposure to environmental pollutants and human microbiome composition are important predisposition factors for tumour development^1,2. Similar to drug molecules, pollutants are typically metabolized in the body, which can change their carcinogenic potential and affect tissue distribution through altered toxicokinetics³. Although recent studies demonstrated that human-associated microorganisms can chemically convert a wide range of xenobiotics and influence the profile and tissue exposure of resulting metabolites^4,5, the effect of microbial biotransformation on chemical-induced tumour development remains unclear. Here we show that the depletion of the gut microbiota affects the toxicokinetics of nitrosamines, which markedly reduces the development and severit

SUBMITTER: Roje B 

PROVIDER: S-EPMC11358042 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature