Dietary fatty acids and gallstone risk: insights from NHANES and Mendelian randomization analysis.

ABSTRACT:

Background

Prior research suggests polyunsaturated fatty acids (PUFA) may prevent gallstones, but evidence on saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) is limited. This study aims to explore the associations between fatty acids and gallstones using a large sample of American population and Mendelian randomization (MR) methods.

Methods

The cross-sectional study involved 6,629 participants from the National Health and Nutrition Examination Survey (NHANES) 2017-2020. Logistic regression and restricted cubic spline (RCS) analysis were conducted after stratifying by gender subgroups. Two-sample MR analysis was used to explore the causal relationship between fatty acids and gallstones without confounding factors.

Results

In females, higher SFA intak

SUBMITTER: Wang M 

PROVIDER: S-EPMC11358065 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature