Changes in oral, skin, and gut microbiota in children with atopic dermatitis: a case-control study.

ABSTRACT:

Introduction

Atopic dermatitis (AD) is a common clinical recurrent atopic disease in dermatology, most seen in children and adolescents. In recent years, AD has been found to be closely associated with microbial communities.

Methods

To explore the synergistic effects between colonizing bacteria from different sites and AD, we comparatively analyzed the skin, oral, and gut microbiota of children with AD (50 individuals) and healthy children (50 individuals) by 16S rRNA gene sequencing. Twenty samples were also randomly selected from both groups for metabolic and macrogenomic sequencing.

Results

The results of our sequencing study showed reduced microbiota diversity in the oral, skin, and gut of children with AD (P < 0.05). Metabolomics analysis showed that serot

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11358084 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature