Enhanced enrichment of extracellular vesicles for laboratory and clinical research from drop-sized blood samples.

ABSTRACT: In the realm of biomedical advancement, extracellular vesicles (EVs) are revolutionizing our capacity to diagnose, monitor, and predict disease progression. However, the comprehensive exploration and clinical application of EVs face significant limitations due to the current isolation techniques. The size exclusion chromatography, commercial precipitation reagents, and ultracentrifugation are frequently employed, necessitating skilled operators and entailing challenges related to consistency, reproducibility, quality, and yields. Notably, the formidable challenge of extracellular vesicle isolation persists when dealing with clinical samples of limited availability. This study addresses these challenges by aiming to devise a rapid, user-friendly, and high-recovery EVs isolation technique ta

SUBMITTER: Guerrero-Alba A 

PROVIDER: S-EPMC11358096 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature