Sex-specific alterations in the gut and lung microbiome of allergen-induced mice.

ABSTRACT:

Introduction

Recent evidence has demonstrated that the microbiome is a driver of the underlying pathophysiological mechanisms of respiratory disease. Studies have indicated that bacterial metabolites produced in the gut and lung can impact lung inflammation and immune cell activity, affecting disease pathology. Despite asthma being a disease with marked sex differences, experimental work linking microbiomes and asthma has not considered the sex variable.

Methods

To test the hypothesis that the lung and gut microbial composition impacts allergic lung inflammation in a sex-specific manner, we evaluated lung and gut microbiome alterations in a mouse model of allergic inflammation and assessed their association with lung function and inflammation phenotypes. For this, we exposed

SUBMITTER: Ekpruke CD 

PROVIDER: S-EPMC11358121 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature