Developing an image-based grading scale for peripheral drusen to investigate associations of peripheral drusen type with age-related macular degeneration.

ABSTRACT: Age-related macular degeneration (AMD) is a leading cause of blindness. It is associated with peripheral drusen which has not been categorized. We investigated peripheral drusen to validate an image grading system and to understand possible associations between peripheral drusen and AMD. We collated clinical data, ultra-widefield (UWF) pseudocolor fundus images and Spectral-Domain Optical Coherence Tomography (SD-OCT) scans from consecutive retinal patients. SD-OCT scans were used to determine AMD stage. A masked retinal specialist recorded the types of peripheral drusen observed in UWF images. Eyes whose UWF images did not pass quality screening and those without AMD and peripheral drusen were excluded from the study. Statistical tests were utilized to determine the validity of our gradin

SUBMITTER: Sharma P 

PROVIDER: S-EPMC11358136 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature