Distinct roles of monkey OFC-subcortical pathways in adaptive behavior.

ABSTRACT: Primates must adapt to changing environments by optimizing their behavior to make beneficial choices. At the core of adaptive behavior is the orbitofrontal cortex (OFC) of the brain, which updates choice value through direct experience or knowledge-based inference. Here, we identify distinct neural circuitry underlying these two separate abilities. We designed two behavioral tasks in which two male macaque monkeys updated the values of certain items, either by directly experiencing changes in stimulus-reward associations, or by inferring the value of unexperienced items based on the task's rules. Chemogenetic silencing of bilateral OFC combined with mathematical model-fitting analysis revealed that monkey OFC is involved in updating item value based on both experience and inference. In viv

SUBMITTER: Oyama K 

PROVIDER: S-EPMC11358305 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature