Intelligent drugs based on notch protein remodeling: a defensive targeting strategy for tumor therapy.

ABSTRACT: In the process of tumor treatment, systemic drug administration is hindered by biological barriers, leading to the retention of a large number of drug molecules in healthy tissues and causing unavoidable side effects. The precise deployment of drugs at the tumor site is expected to alleviate this phenomenon. Here, we take endostatin and Her2 (+) tumors as examples and develop an intelligent drug with simple "wisdom" by endowing mesenchymal stem cells (MSCs) with an intelligent response program (iMSC^Endostatin). It can autonomously perceive and distinguish tumor cells from non-tumor cells, establishing a logical connection between tumor signals and drug release. Enable it to selectively deploy drugs at the tumor site, thereby locking the toxicity of drugs at the tumor site. Unlik

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11358381 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature