3D small-scale dosimetry and tumor control of ²²⁵Ac radiopharmaceuticals for prostate cancer.

ABSTRACT: Radiopharmaceutical therapy using α -emitting 225 Ac is an emerging treatment for patients with advanced metastatic cancers. Measurement of the spatial dose distribution in organs and tumors is needed to inform treatment dose prescription and reduce off-target toxicity, at not only organ but also sub-organ scales. Digital autoradiography with α -sensitive detection devices can measure radioactivity distributions at 20-40 μm resolution, but anatomical characterization is typically limited to 2D. We collected digital autoradiographs across whole tissues to generate 3D dose volumes and used them to evaluate the simultaneous tumor control and regional kidney dosimetry of a novel therapeutic radiopharmaceutical for prostate cancer, [²²⁵Ac]Ac-Macropa-PEG₄-YS5, in mice. 22Rv

SUBMITTER: Peter R 

PROVIDER: S-EPMC11358493 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature