The differential expression of adipose tissue genes in short, medium and long-term periods after bariatric surgery.

ABSTRACT: Bariatric surgery is an approved treatment for obesity that consistently improves metabolic syndrome, with well-documented beneficial effects on dyslipidemia, cardiovascular risk, nonalcoholic fatty liver disease and glucose homeostasis. In this study, we determined the differential expression genes in three periods after bariatric surgery: short-term (4-months), medium-term (1- and 2-years), and long-term (5-years) periods. Two microarray profiles were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified by comparing the expression of adipose tissue genes before surgery compared to short, medium and long-term periods following surgery. Shared DEGs for the medium-term were evaluated by comparing the DEGs for both 1 and 2 years. 1

SUBMITTER: Mahjoubin-Tehran M 

PROVIDER: S-EPMC11358539 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature